For the Vanishing Point Contest
A trip to orbit:
The Rocketplane® XP Vehicle is a four-seat fighter-sized vehicle fitted with a delta wing and a V-tail which provide good flight characteristics both subsonically and supersonically. The vehicle is powered by both turbojet engines and a rocket engine, enabling it to accelerate to speeds just over 3,500 feet per second (2,386 miles per hour) and reach altitudes in excess of 330,000 feet (100 kilometers) providing the sensation of weightlessness for three to four minutes!
too bad I am disqualified :(
Thursday, January 18, 2007
Can Tylenol Make You Stoned?
Probably not, but it's interesting that it's mode of action is based on activating cannabinoid receptors. I wonder if the Ant-Drug lobby will try to get rid of tylenol. Or at least confiscate it at airports.
Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever. It occupies a unique position among analgesic drugs. Unlike NSAIDs it is almost unanimously considered to have no antiinflammatory activity and does not produce gastrointestinal damage or untoward cardiorenal effects. Unlike opiates it is almost ineffective in intense pain and has no depressant effect on respiration. Although paracetamol has been used clinically for more than a century, its mode of action has been a mystery until about one year ago, when two independent groups (Zygmunt and colleagues and Bertolini and colleagues) produced experimental data unequivocally demonstrating that the analgesic effect of paracetamol is due to the indirect activation of cannabinoid CB(1) receptors. In brain and spinal cord, paracetamol, following deacetylation to its primary amine (p-aminophenol), is conjugated with arachidonic acid to form N-arachidonoylphenolamine, a compound already known (AM404) as an endogenous cannabinoid. The involved enzyme is fatty acid amide hydrolase. N-arachidonoylphenolamine is an agonist at TRPV1 receptors and an inhibitor of cellular anandamide uptake, which leads to increased levels of endogenous cannabinoids; moreover, it inhibits cyclooxygenases in the brain, albeit at concentrations that are probably not attainable with analgesic doses of paracetamol. CB(1) receptor antagonist, at a dose level that completely prevents the analgesic activity of a selective CB(1) receptor agonist, completely prevents the analgesic activity of paracetamol. Thus, paracetamol acts as a pro-drug, the active one being a cannabinoid. These findings finally explain the mechanism of action of paracetamol and the peculiarity of its effects, including the behavioral ones. Curiously, just when the first CB(1) agonists are being introduced for pain treatment, it comes out that an indirect cannabino-mimetic had been extensively used (and sometimes overused) for more than a century.
Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever. It occupies a unique position among analgesic drugs. Unlike NSAIDs it is almost unanimously considered to have no antiinflammatory activity and does not produce gastrointestinal damage or untoward cardiorenal effects. Unlike opiates it is almost ineffective in intense pain and has no depressant effect on respiration. Although paracetamol has been used clinically for more than a century, its mode of action has been a mystery until about one year ago, when two independent groups (Zygmunt and colleagues and Bertolini and colleagues) produced experimental data unequivocally demonstrating that the analgesic effect of paracetamol is due to the indirect activation of cannabinoid CB(1) receptors. In brain and spinal cord, paracetamol, following deacetylation to its primary amine (p-aminophenol), is conjugated with arachidonic acid to form N-arachidonoylphenolamine, a compound already known (AM404) as an endogenous cannabinoid. The involved enzyme is fatty acid amide hydrolase. N-arachidonoylphenolamine is an agonist at TRPV1 receptors and an inhibitor of cellular anandamide uptake, which leads to increased levels of endogenous cannabinoids; moreover, it inhibits cyclooxygenases in the brain, albeit at concentrations that are probably not attainable with analgesic doses of paracetamol. CB(1) receptor antagonist, at a dose level that completely prevents the analgesic activity of a selective CB(1) receptor agonist, completely prevents the analgesic activity of paracetamol. Thus, paracetamol acts as a pro-drug, the active one being a cannabinoid. These findings finally explain the mechanism of action of paracetamol and the peculiarity of its effects, including the behavioral ones. Curiously, just when the first CB(1) agonists are being introduced for pain treatment, it comes out that an indirect cannabino-mimetic had been extensively used (and sometimes overused) for more than a century.
What Did I Get My Niece for XMas?
Fizz Wizard Reaction Kit
Space Sand
Safety Goggles
Periodic Table of Elements Poster with Bios
Cool Blue Light Experiment Kit
Glowing Gel Experiment Kit
Rubber Flubber Experiment Kit
Chemistry Wiz – Solids, Liquids and Gases
My First Chemistry Kit
Amethyst Crystal Kit
Rose Quartz Crystal Kit
Our Solar System iCD
Keychain Laser Pointer
there is a theme here....
Space Sand
Safety Goggles
Periodic Table of Elements Poster with Bios
Cool Blue Light Experiment Kit
Glowing Gel Experiment Kit
Rubber Flubber Experiment Kit
Chemistry Wiz – Solids, Liquids and Gases
My First Chemistry Kit
Amethyst Crystal Kit
Rose Quartz Crystal Kit
Our Solar System iCD
Keychain Laser Pointer
there is a theme here....
Why Am I Excited About This?
Gears of War:
Despite the mantra of many gamers, graphics do matter. (As Bleszinski told GameSpy last year, "[U]ntil recently you couldn't express a nuanced brow raise or a wry grin which can say a thousand things to the user. Instead we'd just go, 'That's hard, let's give her some huge boobs and call it a day.' ")
I don't play this genre much, so why do I care? Because Microsoft is doing the next version of City of Heroes, Marvel Universe, and this is what I am looking forward to :)
Despite the mantra of many gamers, graphics do matter. (As Bleszinski told GameSpy last year, "[U]ntil recently you couldn't express a nuanced brow raise or a wry grin which can say a thousand things to the user. Instead we'd just go, 'That's hard, let's give her some huge boobs and call it a day.' ")
I don't play this genre much, so why do I care? Because Microsoft is doing the next version of City of Heroes, Marvel Universe, and this is what I am looking forward to :)
Codependant Enabler
There is a very interesting debate going on over at AS on the top of the religious and the atheists. Interesting because Sullivan's logic is clearly wrong, i.e. he's trying to have it both ways, believing that reason leads to faith. His opponent, Sam Harris, keeps calling him on this and pointing out that reason leads to less faith, not more.
Personally, I think faith is a fine thing, if you have it, good for you. Where I step off is when you try to hedge your faith (believing something without evidence) and say it's based on reason (i.e. evidence). Nick and I did a quiet round or two last week, but frankly I dont have the energy or inclination to do a proper job. Nick's basic premise was "assume there is a god. based on that assumption, faith is logical", mine was "why would you assume there is a god? There is no evidence", it very quickly degenerates into which is the more reasonable set of assumptions. Personally, I've also thought the assumption of god without evidence is specious logic. I could use the same one to assume the existence of the Devil, or of just about any other mythological figure and would be unable to prove they dont exist (the debate usually ends when one shows that one is unable to disprove the existence of Santa Claus. Ends in a huff with a sentence along the lines of "you're not taking this seriously"). Just because you cant prove something doesn’t exist, doesn’t justify the assumption that it must.
In this dispatch Sam makes the argument that religious moderates are the codependant enablers of religious extremists, i.e. if you pick and chose which parts of religion to believe, choosing some and ignoring others, you enable extremists to do the same and have access to the same arguments, just with a different spin. If you're a moderate, it's difficult to say exactly what you have faith in, and back it up with any kind of coherent religious argument. Sam says, basically, if you throw out parts of your religion, why not toss out the whole thing as a bad investment, shudder the doors to the churches and spend the resources on more useful capitalist endeavors?
I eagerly await Sully's reply. He may come up with an argument I haven't seen before.
Edit: Having read Sam's note twice now, I think Sully has to change the subject in his reply. Sam is just too spot on.
BTW, in case you were wondering, I don't think we will ever live in a world free of religion. The human brain is just built too well as a belief engine. There will always be mystics, faith and foolishness in human history. I have not dispared though that religion will take on a less violent and noxious form in the future.
Personally, I think faith is a fine thing, if you have it, good for you. Where I step off is when you try to hedge your faith (believing something without evidence) and say it's based on reason (i.e. evidence). Nick and I did a quiet round or two last week, but frankly I dont have the energy or inclination to do a proper job. Nick's basic premise was "assume there is a god. based on that assumption, faith is logical", mine was "why would you assume there is a god? There is no evidence", it very quickly degenerates into which is the more reasonable set of assumptions. Personally, I've also thought the assumption of god without evidence is specious logic. I could use the same one to assume the existence of the Devil, or of just about any other mythological figure and would be unable to prove they dont exist (the debate usually ends when one shows that one is unable to disprove the existence of Santa Claus. Ends in a huff with a sentence along the lines of "you're not taking this seriously"). Just because you cant prove something doesn’t exist, doesn’t justify the assumption that it must.
In this dispatch Sam makes the argument that religious moderates are the codependant enablers of religious extremists, i.e. if you pick and chose which parts of religion to believe, choosing some and ignoring others, you enable extremists to do the same and have access to the same arguments, just with a different spin. If you're a moderate, it's difficult to say exactly what you have faith in, and back it up with any kind of coherent religious argument. Sam says, basically, if you throw out parts of your religion, why not toss out the whole thing as a bad investment, shudder the doors to the churches and spend the resources on more useful capitalist endeavors?
I eagerly await Sully's reply. He may come up with an argument I haven't seen before.
Edit: Having read Sam's note twice now, I think Sully has to change the subject in his reply. Sam is just too spot on.
BTW, in case you were wondering, I don't think we will ever live in a world free of religion. The human brain is just built too well as a belief engine. There will always be mystics, faith and foolishness in human history. I have not dispared though that religion will take on a less violent and noxious form in the future.
Wednesday, January 17, 2007
Tuesday, January 09, 2007
Last Man Standing
From Wonkette:
Guess who somehow found room in his liver for some backbone? Teddy Kennedy!
The sole survivor of the CIA’s bold 1960s campaign to rid Washington of Kennedys, Senator Ted says Congress will be blocking whatever crazy “surge” Bush will announce tomorrow.
LOLerskates!
Guess who somehow found room in his liver for some backbone? Teddy Kennedy!
The sole survivor of the CIA’s bold 1960s campaign to rid Washington of Kennedys, Senator Ted says Congress will be blocking whatever crazy “surge” Bush will announce tomorrow.
LOLerskates!
Friday, January 05, 2007
New Link
I'm going to offically add Hankspot to my blogroll to the right. Not a lot of posts/week ( a plus in my book), many of them interesting. I agree with some, disagree with others. If you enjoy some of these posts, you may enjoy some of his.
Hank's another CoH person who (I think) spends more time in game than out. Well known on the server, he's a decent guy (even if his style is very different than mine). He's had some interesting and amusing battles with some individuals in the Goon Squad.
As some of you know, my son Geoff has been underwriting my Something Awful membership for years now, making me a crypto-goon. I have not yet had the time, energy or inclination to purposely team with the Goons, but in the whole they've been decent players individually.
And yes, I know the Terrible Secret of Space!
Hank's another CoH person who (I think) spends more time in game than out. Well known on the server, he's a decent guy (even if his style is very different than mine). He's had some interesting and amusing battles with some individuals in the Goon Squad.
As some of you know, my son Geoff has been underwriting my Something Awful membership for years now, making me a crypto-goon. I have not yet had the time, energy or inclination to purposely team with the Goons, but in the whole they've been decent players individually.
And yes, I know the Terrible Secret of Space!
A Rare Tale of Integrity and Engineering
I ran across this the other day while looking for something else. It's a true story of an architect, his building and a surprising lack of ass-covering.
Engineers really do think different. Almost makes me wish I had had the kind of mind it takes to study it.
It also makes me wonder if the novelity is due to the rarity.
In May 1978, while working on another project, LeMessurier discovered that bolts had been used to join the diagonal braces to the columns of the Citicorp tower (by then completed and occupied). This surprised him because he had originally specified that the joints should be welded (a proper weld between two metal pieces is usually stronger than the individual metal pieces). However, when he checked into the matter, he found that the contractor had proposed the change to bolts to make construction easier and less expensive, and that, after carrying out some calculations to ensure that the bolts were strong enough, LeMessurier's chief engineer had approved the change. This was all proper practice, and so LeMessurier did not think any more of the issue at the time.
Approximately a month later, LeMessurier received a phone call from a student working on a senior-year project. To this day he does not know who the student was, but the student said, in effect: "Sir, can I bother you for a minute? I know you are a very busy man but my professor thinks you should have put the columns on the corners to better resist the loads which occur due to wind blowing on the tower."
The rest of the story
Engineers really do think different. Almost makes me wish I had had the kind of mind it takes to study it.
It also makes me wonder if the novelity is due to the rarity.
In May 1978, while working on another project, LeMessurier discovered that bolts had been used to join the diagonal braces to the columns of the Citicorp tower (by then completed and occupied). This surprised him because he had originally specified that the joints should be welded (a proper weld between two metal pieces is usually stronger than the individual metal pieces). However, when he checked into the matter, he found that the contractor had proposed the change to bolts to make construction easier and less expensive, and that, after carrying out some calculations to ensure that the bolts were strong enough, LeMessurier's chief engineer had approved the change. This was all proper practice, and so LeMessurier did not think any more of the issue at the time.
Approximately a month later, LeMessurier received a phone call from a student working on a senior-year project. To this day he does not know who the student was, but the student said, in effect: "Sir, can I bother you for a minute? I know you are a very busy man but my professor thinks you should have put the columns on the corners to better resist the loads which occur due to wind blowing on the tower."
The rest of the story
Thursday, January 04, 2007
I Really and Truely Did This
Here
Although I didn't know the term "Turning Machine". I had worked out a secret code for sending messages on candy-button paper when I was 6, with the "clever" notion that you could eat the message afterward or, better yet, eat some of the reamining buttons and send a reply.
My scheme crashed directly into reality when the first person I gave my siliva-covered, half-eaten strip of candy to (my uncle as I recall), looked disgusted and threw it away.
Although I didn't know the term "Turning Machine". I had worked out a secret code for sending messages on candy-button paper when I was 6, with the "clever" notion that you could eat the message afterward or, better yet, eat some of the reamining buttons and send a reply.
My scheme crashed directly into reality when the first person I gave my siliva-covered, half-eaten strip of candy to (my uncle as I recall), looked disgusted and threw it away.
Slight Atheism Debate
Here with Dr. Nick
Nick and I politely take the field, politely click lances, politely return to our camps and each declare to our followers that we were the victors!
With no mention of Santa Claus or the FSM.
Not quite the gusto of a debate with TJIC, but I am also spared the usual tjicistan personal attacks and verbal diarrhea, so I think it's more interesting.
My respect for Nick over TJIC continues to accelerate.
Nick and I politely take the field, politely click lances, politely return to our camps and each declare to our followers that we were the victors!
With no mention of Santa Claus or the FSM.
Not quite the gusto of a debate with TJIC, but I am also spared the usual tjicistan personal attacks and verbal diarrhea, so I think it's more interesting.
My respect for Nick over TJIC continues to accelerate.
Vanguard League Website
I did manage to build a website for my SG last month, and to my utter and complete surprise I find it not only being used, but it has an active Forum.
Check it out when you have a chance. The Trading cards are also my work. There should be more of them as more members send me their pics.
BTW, the Vanguard League is now in second place as a hero group on our server (Victory) and in 5th place over all. :)
Check it out when you have a chance. The Trading cards are also my work. There should be more of them as more members send me their pics.
BTW, the Vanguard League is now in second place as a hero group on our server (Victory) and in 5th place over all. :)
Longish Hiatus Over
I should be back to bloggin more regularly now. I picked up a nasty, nasty bout of the flu in London and have been down with that and the usual Holiday stuff since.
Actually, I have a back log of stuff to post, so there might be a surge before we resume normal operations.
Actually, I have a back log of stuff to post, so there might be a surge before we resume normal operations.
Monday, December 25, 2006
Thursday, December 14, 2006
Heim Theory
If you read the first page of this and you mind isn't blown completely away you either didn't understand it or ... you're not from this planet.
It completely re-invents 20th century physics and makes very accurate predictions which have withstood emperical testing. The gaviton as a soliton of a probabilty-based dimensional extention to 4-space...
Damn!
Interstellar travel just might be within my lifetime afterall.
It completely re-invents 20th century physics and makes very accurate predictions which have withstood emperical testing. The gaviton as a soliton of a probabilty-based dimensional extention to 4-space...
Damn!
Interstellar travel just might be within my lifetime afterall.
Instant Freezing Beer
Because beer comes in a sealed container, it's possible to chill it well below the normal freezing point and still have it in liquid form. This is interesting becasue when you top the top, the pressure drops and the beer freezes solid very quickly.
Here's the whole story.
Note that you can do the reverse process with hot liquids and a microwave oven, i.e. heat water past the boiling point but not have it boil. The trick is to have relavtively pure water with very few nucleation sites. If you add something with a little surface area, e.g. sugar, tea, instant coffee etc. the water will instantly boil up. This is a significant source of injury with tea btw.
Here's the whole story.
Note that you can do the reverse process with hot liquids and a microwave oven, i.e. heat water past the boiling point but not have it boil. The trick is to have relavtively pure water with very few nucleation sites. If you add something with a little surface area, e.g. sugar, tea, instant coffee etc. the water will instantly boil up. This is a significant source of injury with tea btw.
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